Ancient Nutrition Immune Probiotic | Daily Guard Picks

This immune-focused probiotic from Ancient Nutrition supplies 25 billion CFU and four hardy strains to back everyday defenses.

What This Immune Probiotic Actually Delivers

The Immune Once Daily capsule supplies 25 billion colony-forming units at the time of manufacture, built from four resilient microbes: Saccharomyces boulardii, Bacillus clausii, Bacillus subtilis, and Bacillus coagulans. The blend is paired with a prebiotic and postbiotic mix plus botanicals like elderberry and reishi. The design aims at daily gut comfort while giving your immune system steady background help.

Because these strains form spores or are a hardy yeast, they tolerate heat and stomach acid better than many lactobacillus-only formulas. That means fewer worries about cold-chain shipping and a better chance the microbes reach the intestines alive to do their work.

Feature	What It Means	Notes
CFU Count	25B per serving*	*At time of manufacture
Strain Types	S. boulardii; B. clausii; B. subtilis; B. coagulans	Resilient, shelf-stable organisms
Pre/Postbiotics	Acacia fiber & postbiotic compounds	Feeds and signals for gut microbes
Superfoods	Elderberry, reishi, fermented astragalus	Traditional immune allies
Format	Once-daily capsule	No refrigeration listed

Why CFUs, Strains, And Extras Matter

CFU tells you the amount of live microbes. U.S. regulators allow brands to list CFUs, which helps shoppers compare strength by viable count, not just weight. The number isn’t a guarantee of benefit on its own, but it’s the right unit for live microbials. Read the FDA’s update on CFU labeling to see why that matters.

S. boulardii has a long record for gut balance in clinical settings, and Bacillus species bring spore toughness with immune-modulating traits. Together with fiber and postbiotic compounds, you get both living organisms and the signals they produce.

Close Variant: Immune-Support Probiotic By Ancient Nutrition — Who It Suits

This once-daily capsule suits people who want a straightforward routine without yogurts or powders. Travelers, shift workers, teachers, and parents often pick spore-formers for their resilience and simple storage. If you already take a separate multi-strain gut formula, this can serve as an immune-leaning add-on, yet many users run it as their single daily probiotic.

What The Strains Bring To The Table

Saccharomyces boulardii is a probiotic yeast used to support normal stool patterns during antibiotic use and routine travel. Meta-analyses report protective effects for common gut upsets in adults, aligning with its long track record in clinics.

Bacillus clausii is a spore-former studied for immune balance. Reviews describe shifts in cytokines and immunoglobulins, while clinical work in pediatric diarrhea care shows practical value. Spore status gives it the toughness many shoppers want in a shelf-stable capsule.

Bacillus coagulans shows human data on digestion, protein use, and immune markers in select trials. It makes lactic acid and forms spores, supporting survival through gastric acid. Strain identity differs across studies, so treat broad claims with care and track your own response.

Bacillus subtilis appears in multi-strain blends for spore stability and enzyme output. It can bolster microbial diversity and support a balanced gut environment alongside the other species.

About The Extras: Fiber And Botanicals

The acacia fiber serves as a gentle prebiotic, feeding resident microbes. Postbiotics are compounds made by bacteria that can nudge gut and immune cells; adding them sidesteps the need to wait for in-body production. Elderberry and reishi round out the profile with a long history in wellness products. For a neutral overview, see the NCCIH page on elderberry and weigh your own needs.

How To Take It For Best Results

One capsule daily is the standard. Pick a time you can stick with—morning with water or evening after dinner both work. Because these strains are hardy, you don’t need strict food timing. Many users stay consistent for 6–8 weeks before judging results, since gut shifts can be gradual.

Smart Pairings

Pair with balanced fiber from meals, fluids, and steady sleep habits. If you already use a vitamin C or zinc product, check overlap. This immune-centric capsule centers on microbes and botanicals; the brand’s Vitamin C + Probiotics option skews toward micronutrients with a lighter CFU count.

Who Should Skip Or Ask A Clinician

People with central lines or severe illness should avoid live microbes unless a clinician signs off. If you’re on immunosuppressive drugs, talk with your care team first. Those with yeast allergies should be aware that S. boulardii is a yeast. If you react to mushrooms, review the label for reishi and make a plan with your provider.

Evidence Snapshot: What Research Suggests

Human studies tie S. boulardii to fewer common digestive upsets in several settings. Reviews on B. clausii point to immune signaling changes and real-world use during childhood diarrhea care. Trials with specific B. coagulans strains report shifts in inflammatory markers and digestion outcomes. Not every study uses the same strains that brands choose, and outcomes vary, so set realistic expectations and evaluate how you feel over time.

Botanical add-ons like elderberry show mixed findings for seasonal symptoms. Quality, dose, and timing differ widely between products, which explains why results vary person to person.

Label Literacy: Reading This Bottle Like A Pro

Scan for CFU listed per serving, not just milligrams. Look for the phrase “at time of manufacture,” which signals the count when bottled. Shelf life can reduce the number over time, and storage heat speeds that drop. Spore-formers tend to handle real-world shipping better than fragile strains, yet any supplement does best in a cool, dry place.

Next, find the strain names. Some products list only species; others include full strain codes. When codes are present, you can track research more precisely. Without them, use broad-category evidence and your own experience to guide the trial.

Product	CFU Per Serving*	Notable Add-Ons
Immune Once Daily	25B	Elderberry, reishi, astragalus, acacia fiber
Vitamin C + Probiotics	2B	Vitamin C with B. coagulans
Ultimate Formula	50B	Higher CFU multi-strain blend

Safe Use, Storage, And Expectations

Store the bottle away from heat and sun. Travel with a small pill case to keep your routine steady. If you miss a day, just resume; no catch-up needed. Gas or mild bloating can show up in week one while your gut adjusts. If discomfort lingers, take with a meal or pause and talk with your clinician.

When To Re-Evaluate

Re-check after two months. If your digestion feels calmer and you’re getting sick less often, keep going. If nothing changes, switch dose or try a different strain mix. Some people rotate seasonally; others stay steady year-round.

Trusted Sources To Read Next

You can scan the FDA context on colony-forming units and the NCCIH overview on elderberry for balanced background before you buy. Both pages are brand-neutral and easy to skim.